20 ověřených přírodních látek na stres, úzkost a depresi

Comments

1. palo says

   27.12.2017 at 23:51

   Vaše články sú v podstate dobré, ale vyvarujte sa faux pas, lebo v tomto prípade pacienti si môžu poškodiť pečeň. Moje predošlé upozornenie ste vymazali, škoda lebo bolo tam aj vlastné nepríjemné zistenie s užívaním kava-kava. Určite aj toto pôjde do koša, ale aspoň si pozrite nedávno publikované práce.
   J Clin Anesth. 2016 Dec;35:96-98. doi: 10.1016/j.jclinane.2016.07.027. Epub 2016 Aug 9.
   Hepatotoxicity due to red bush tea consumption: a case report.
   Reddy S1, Mishra P2, Qureshi S3, Nair S4, Straker T5.
   Author information
   Abstract
   Many conventional drugs used today, including isoniazid, dapsone, and acetaminophen, are well recognized culprits of hepatotoxicity. With increasing use of complementary and alternative medical therapies, several herbal medicines, such as Ma-Huang, kava, and chaparral leaf, have been implicated as hepatotoxins. Hepatotoxicity may be the most frequent adverse reaction to these herbal remedies when taken in excessive quantities. A myriad of liver dysfunctions may occur including transient liver enzyme abnormalities due to acute and chronic hepatitis. These herbal products are often overlooked as the causal etiologic agent during the evaluation of a patient with elevated liver function tests. We describe a case of hepatotoxicity due to ingestion of red bush tea diagnosed during preoperative assessment of a patient scheduled for laparoscopic appendectomy. Elevated liver enzymes and thrombocytopenia detected in the patient’s laboratory work up confounded the initial diagnosis of acute appendicitis and additional investigations were required to rule out cholecystitis and other causes of hepatitis. Open appendectomy was done uneventfully under spinal anesthesia without any further deterioration of hepatic function.
   KEYWORDS:
   Hepatotoxicity; Herbal tea; Red bush tea; Rooibos; Spinal anesthesia
   Food Chem Toxicol. 2017 Sep;107(Pt A):472-501. doi: 10.1016/j.fct.2016.07.001. Epub 2016 Jul 8.
   Liver toxicity related to herbs and dietary supplements: Online table of case reports. Part 2 of 5 series.
   Brown AC1.
   Author information

   Abstract
   BACKGROUND:
   No online current list of potentially life-threatening, hepatotoxic herbs and dietary supplements based on PubMed case reports exists in a summarized tabular form.
   METHODS:
   Documented case reports of herbs or dietary supplements (DS; includes herbs) appearing to contribute to liver injury were used to create an online “DS Toxic Table” of potentially hepatotoxic herbs and dietary supplements (PubMed, 1966 to June, 2016, and cross-referencing). The spectrum of DS induced liver injuries (DSILI) included elevated liver enzymes, hepatitis, steatosis, cholestasis, hepatic necrosis, hepatic fibrosis, hepatic cirrhosis, veno-occlusive disease, acute liver failure requiring a liver transplant, and death.
   RESULTS:
   Over the past 50 years, approximately 21 herbs (minus germander and usnic acid that are no longer sold) and 12 dietary supplements (minus the nine no longer sold and vitamin A & niacin due to excess intake) posed a possible risk for liver injures in certain individuals. The herbs with the most number of reported publications (but not cases studies) in descending order, were germander, black cohosh, kava extract, and green tea extract.
   CONCLUSION:
   These online DS Toxic Tables will contribute to continued Phase IV post marketing surveillance to detect possible liver toxicity cases and serve to forewarn consumers, clinicians, and corporations.
   Copyright © 2017 Elsevier Ltd. All rights reserved.
   KEYWORDS:
   Dietary supplement; Hepatitis; Hepatotoxicity; Herb; Liver; Toxicity
   Dtsch Med Wochenschr. 2006 May 26;131(21):1214-7.
   [Acute hepatitis due to kava-kava and St John’s Wort: an immune-mediated mechanism?].

   [Article in German]
   Musch E1, Chrissafidou A, Malek M.
   Author information
   Abstract
   HISTORY AND CLINICAL FINDINGS:
   In an otherwise healthy 48-year-old female patient, acute hepatitis with transaminase increase (GOT up to 613 U/l, GPT up to 752 U/l), inconspicuous hepatitis serology findings, negative autoantibody status and negative virus serology was observed after a 10-week long intake of kava-kava (1-3 x 200 mg/day) and St John’s Wort (1 x 425 mg/day). Biopsy of the liver showed lobular and portal necroinflammatory activity without indication of cirrhosis.
   DIAGNOSIS:
   Due to these findings with proven T-cell activity (lymphocyte typing, neopterin determination) as well as the aetiopathology, this form of hepatitis with histological characteristics of a nutritive/medicinal toxic origin was classified as induced immunologic idiosyncratic hepatitis, possibly in terms of an antibody-negative autoimmune hepatitis.
   TREATMENT AND CLINICAL COURSE:
   Discontinuation of the existing medication and simultaneous onset of immunosuppressive combination therapy of cortisone, azathioprine and ursodeoxycholic acid resulted in normalisation of the liver parameters within a period of two months.
   CONCLUSION:
   On the one hand, it appears that simultaneous intake of St John’s Wort possibly potentiates the toxicity of kavapyrones. On the other hand, an immune-mediated mechanism, induced by kava-kava, cannot be completely excluded in the present case. It must be stressed that in patients with autoimmune hepatitis, precise history of medication intake should also be available.

   Odpovědět

   • redakce says

     28.12.2017 at 16:02

     náš článek nemluví o dlouhodobém užívání

     Odpovědět